Shanmugam G, Polavarapu PL, Hallgas B, et al. Molecules, morphology, and ecology indicate a recent, amphibious ancestry for echidnas. Comparative genomics in vertebrates: a role for the platypus. Concerted birth-and-death evolution of multigene families. Comp Biochem Physiol A Mol Integr Physiol. Review of the monotreme fossil record and comparison of palaeontological and molecular data. Observations on the femoral gland of Ornithorhynchus and its secretion together with an experimental enquiry concerning its supposed toxic action. Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes. Margulies EH, Maduro VV, Thomas PJ, et al. Morphological and histochemical observations on the crural gland-spur apparatus of the echidna ( Tachyglossus aculeatus) together with comparative observations on the femoral gland-spur apparatus of the duckbilled platypus ( Ornithorhyncus anatinus). A component of platypus ( Ornithorhynchus anatinus) venom forms slow-kinetic cation channels. Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus ( Ornithorhynchus anatinus) venom. Mammalian peptide isomerase: platypus-type activity is present in mouse heart. Platypus venom: source of novel compounds. The origin of snakes and evolution of the venom apparatus. A kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta1 signaling cascade. ![]() Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. The venom of the platypus ( Ornithorhynchus anatinus). Were mammals originally venomous? Acta Palaeontol Pol. The monotreme genome: a patchwork of reptile, mammal and unique features? Comp Biochem Physiol A Comp Physiol. The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms. Platypus envenomation – a painful learning experience. Kallikrein-like proteinase from bushmaster snake venom. ![]() Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans. Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells. The natriuretic peptide (OVCNP-39) from platypus ( Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. A C-type natriuretic peptide from the venom of the platypus ( Ornithorhynchus anatinus): structure and pharmacology. A pharmacological and biochemical investigation of the venom from the platypus ( Ornithorhynchus anatinus). Australian National University 1998ĭe Plater G, Martin RL, Milburn PJ. Fractionation, primary structural characterisation and biological activities of polypeptides from the venom of the platypus ( Ornithorhynchus anatinus). Sydney: Angus & Robinson Ltd 1927.ĭe Plater G. Crotalus durissus collilineatus venom gland transcriptome: analysis of gene expression profile. This process is experimental and the keywords may be updated as the learning algorithm improves.īoldrini-França J, Rodrigues RS, Fonseca FPP, et al. These keywords were added by machine and not by the authors. The paper concludes by providing insights into how these venom peptides could be developed into novel therapeutics for human use. ![]() It first provides an overview of the genes and molecules involved in venom production and focuses on how these molecules explain the symptoms of envenomation: allodynia, hyperalgesia, swelling and changes to blood pressure. This paper reviews the current literature on platypus venom, focusing primarily on recent advances which have been made since the sequencing of the platypus genome and venom gland transcriptome. Venom delivery is believed to provide individuals with an advantage over conspecifics throughout the breeding season. During the breeding season they are able to deliver venom through spurs located on their hind legs. Is a monotreme, an egg-laying mammal, found only in Australia.
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